Amitriptyline hydrochloride
Cat. No.：YN321524
| 产品名称: | Amitriptyline hydrochloride |
| CAS No.: | 549-18-8 |
| Chemical Name: | 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride |
| Synonyms: | 盐酸阿米替林 |
| 分子量: | 313.86 |
| 分子式: | C₂₀H₂₄ClN |
| SMILES: | CN(C)CC/C=C1C2=CC=CC=C2CCC3=C\1C=CC=C3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amitriptyline hydrochloride 是一种血清素再摄取转运体 (SERT) 和去甲肾上腺素再摄取转运体 (NET) 抑制剂，对人的 SERT 和 NET 作用的Ki值分别为 3.45 nM 和 13.3 nM。Amitriptyline hydrochloride 还与多巴胺再摄取转运体 (DAT) 结合，其Ki为 2.58 μM。盐Amitriptyline hydrochloride 也抑制肾上腺素能受体 (adrenergic receptor)、毒蕈碱受体 (muscarin |
| IC50和靶点: | [{name:"5-HT1A Receptor:450 nM (IC50)"},{name: "5-HT1B Receptor:40 nM (IC50)"},{name: "5-HT2A Receptor:4 nM (IC50)"},{name: "5-HT2B Receptor:40 nM (IC50)"},{name: "5-HT2C Receptor:6 nM (IC50)"},{name: "H1 Receptor:1.1 nM (IC50)"},{name: "H3 receptor:1 μM (IC50)"},{name: "H4 receptor:33.6 nM (IC50)"},{name: "SERT:3.45 nM (Ki)"},{name: "NET:13.3 nM (Ki)"},{name: "DAT:2.58 μM (Ki)"},{name: "Adrenergic receptor:24 nM (IC50)"},{name: "muscarinic receptor:7.2 nM (IC50)'}, 'TrkA', 'TrkB'] |
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| Solvent & Solubility: |
Spencer, P.S.Review of the pharmacology of existing antidepressantsBr. J. Clin. Pharmacol.4(Suppl 2),57S-68S(1977)
