Ramosetron Hydrochloride
Cat. No.：YN321544
| 产品名称: | Ramosetron Hydrochloride |
| CAS No.: | 132907-72-3 |
| Chemical Name: | (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-methanone, monohydrochloride |
| Synonyms: | 盐酸雷莫司琼; YM060 |
| 分子量: | 315.80 |
| 分子式: | C₁₇H₁₈ClN₃O |
| SMILES: | O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H](C3)CCC4=C3NC=N4.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ramosetron (YM060) Hydrochloride 是一种 5-HT3 受体拮抗剂，用于研究恶心和呕吐。 |
| IC50和靶点: | |
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Miyata, K., Kamato, T., Nishida, A., et al.Pharmacologic profile of (R)-5-[(1-methyl-3-indolyl)carbonyl]- 4,5,6,7-tetrahydro-1H-benzimidazol hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissueJ. Pharmacol. Exp. Ther.259(1),15-21(1991)
Manning, D.D., Cioffi, C.L., Usyatinsky, A., et al.Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndromeBioorg. Med. Chem. Lett.21(1),58-61(2011)
Manabe, N., Rao, A.S., Wong, B.S., et al.Emerging pharmacologic therapies for irritable bowel syndromeCurr. Gastroenterol. Rep.12(5),408-416(2010)
Mihara, T., Tojo, K., Uchimoto, K., et al.Reevaluation of the effectiveness of ramosetron for preventing postoperative nausea and vomiting: A systematic review and meta-analysisAnesth. Analg.117(2),329-339(2013)
