Dihydroergotamine mesylate
Cat. No.：YN321556
| 产品名称: | Dihydroergotamine mesylate |
| CAS No.: | 6190-39-2 |
| Chemical Name: | (5'α,10α)-9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-ergotaman-3',6',18-trione, methanesulfonate |
| Synonyms: | Dihydroergotamine mesilate |
| 分子量: | 679.78 |
| 分子式: | C₃₄H₄₁N₅O₈S |
| SMILES: | O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@](NC([C@@H](CN(C)[C@]3([H])C4)C[C@]3([H])C5=C6C4=CNC6=CC=C5)=O)(C)C7=O)N7[C@H]2CC8=CC=CC=C8.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dihydroergotamine甲磺酸盐为麦角生物碱，可作用于偏头疼。 |
| IC50和靶点: | |
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Lesage, A.S., Wouters, R., Gompel, P.V., et al.Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell linesBr. J. Pharmacol.123(8),1655-1665(1998)
Toll, L., Berzetei-Gurske, I.P., Polgar, W.E., et al.Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medicationsNIDA Res. Monogr.178,440-466(1998)
U'Prichard, D.C., Greenberg, D.A., and Snyder, S.H.Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptorsMol. Pharmacol.13(3),454-473(1977)
Kayser, V., Aubel, B., Hamon, M., et al.The antimigraine 5-HT1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic painBr. J. Pharmacol.137(8),1287-1297(2002)
