Metergoline
Cat. No.：YN321600
CAS No. ：17692-51-2
| 产品名称: | Metergoline |
| CAS No.: | 17692-51-2 |
| Chemical Name: | N-[[(8β)-1,6-dimethylergolin-8-yl]methyl]-carbamic acid, phenylmethyl ester |
| Synonyms: | 甲麦角林 |
| 分子量: | 403.52 |
| 分子式: | C₂₅H₂₉N₃O₂ |
| SMILES: | O=C(OCC1=CC=CC=C1)NC[C@H](C[C@@]23[H])CN(C)[C@]2([H])CC4=CN(C)C5=CC=CC3=C54 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Metergoline是一种麦角灵化学类的精神药物，常用作各种血清素和多巴胺受体的配体。 |
| IC50和靶点: | [{name:"5-HT2A Receptor:8.64 (pKi)"},{name: "5-HT2B Receptor:8.75 (pKi)"},{name: "5-HT2C Receptor:8.75 (pKi)"},{name: "Human 5-HT7 Receptor:16 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Millan, M.J., Newman-Tancredi, A., Lochon, S., et al.Specific labelling of serotonin 5-HT1B receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterizationPharmacol. Biochem. Behav.71(4),589-598(2002)
Knight, A.R., Misra, A., Quirk, K., et al.Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptorsNaunyn Schmiedebergs Arch. Pharmacol.370(2),114-123(2004)
Knight, J.A., Smith, C., Toohey, N., et al.Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonistsMol. Pharmacol.75(2),374-380(2009)
Yeom, H.D., and Lee, J.-H.Regulation of human Kv1.4 channel activity by the antidepressant metergolineBiol. Pharm. Bull.39(6),1069-1072(2016)
Lee, J.-H., Liu, J., Shin, M., et al.Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na+ channels expressed in Xenopus oocytesActa Pharmacol. Sin.35(7),862-868(2014)
