Rotundine
Cat. No.：YN321707
| 产品名称: | Rotundine |
| CAS No.: | 483-14-7 |
| Chemical Name: | 5,8,13,13aS-tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine |
| Synonyms: | 罗通定; (-)-Tetrahydropalmatine; L-Tetrahydropalmatine |
| 分子量: | 355.43 |
| 分子式: | C₂₁H₂₅NO₄ |
| SMILES: | COC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rotundine 是多巴胺D1，D2和D3受体的拮抗剂，其IC50值分别为 166 nM， 1.4 μM 和 3.3 μM。 Rottroine 也是5-HT1A的拮抗剂，IC50值为 370 nM。 |
| IC50和靶点: | [{name:"D1 Receptor:166 nM (IC50)"},{name: "D2 Receptor:1400 nM (IC50)"},{name: "D3 Receptor:3300 nM (IC50)"},{name: "5-HT1A Receptor:370 nM (IC50)"}] |
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Hu, J.-Y., and Jin, G.-Z.Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatineZhongguo Yao Li Xue Bao20(8),715-719(1999)
Lee, B., Sur, B., Yeom, M., et al.L-tetrahydropalmatine ameliorates development of anxiety and depression-related symptoms induced by single prolonged stress in ratsBiomol. Ther. (Seoul),(2014)
Han, Y., Zhang, W., Tang, Y., et al.l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in ratsPLoS One7(6),(2012)
