Jatrorrhizine chloride
Cat. No.：YN321730
| 产品名称: | Jatrorrhizine chloride |
| CAS No.: | 6681-15-8 |
| Chemical Name: | 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-dibenzo[a,g]quinolizinium, monochloride |
| Synonyms: | FJ146885 |
| 分子量: | 373.83 |
| 分子式: | C₂₀H₂₀ClNO₄ |
| SMILES: | COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Jatrorrhizine chloride 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗疟原虫和抗氧化活性。Jatrorrhizine chloride 是有效的，具有口服活性的乙酰胆碱酯酶 (AChE) (IC50=872 nM) 的抑制剂，是对 BuChE 的选择性为 115 倍。Jatrorrhizine chloride 通过抑制 uptake-2 transporter 的活性减少血清素 (5-HT) 和去甲肾上腺素 (NE) 的摄取。 |
| IC50和靶点: | |
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Liu, R., Cao, Z., Pan, Y., et al.Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cellsAnticancer Drugs24(7),667-676(2013)
Yang, W., She, L., Yu, K., et al.Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse modelMol. Med. Rep.14(4),3277-3284(2016)
Zuo, F., Nakamura, N., Akao, T., et al.Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometryDrug Metab. Dispos.34(12),2064-2072(2006)
