Isocorynoxeine
Cat. No.：YN321734
CAS No. ：51014-29-0
| 产品名称: | Isocorynoxeine |
| CAS No.: | 51014-29-0 |
| Chemical Name: | (αE,1′S,6′R,7′S,8′aS)-6′-ethenyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, methyl ester |
| Synonyms: | 异去氢钩藤碱; 7 |
| 分子量: | 382.45 |
| 分子式: | C₂₂H₂₆N₂O₄ |
| SMILES: | O=C(NC1=C2C=CC=C1)[C@@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](C=C)C4)([H])N4CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Isocorynoxeine，一种与钩藤碱有关的生物碱，对5-HT2A受体介导的电流反应呈剂量依赖性抑制，IC50为 72.4 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yuan, D., Ma, B., Wu, C., et al.Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microgliaJ. Nat. Prod.71(7),1271-1274(2008)
Xi, W., Chen, F., Sun, J., et al.Isolation and identification of twelve metabolites of isocorynoxeine in rat urine and their neuroprotective activities in HT22 cell assayPlanta Med.81(1),46-55(2015)
Li, T., Xu, K., Che, D., et al.Endothelium-independent vasodilator effect of isocorynoxeine in vitro isolated from the hook of Uncaria rhynchophylla (Miquel)Naunyn Schmiedebergs Arch. Pharmacol.391(11),1285-1293(2018)
Matsumoto, K., Morishige, R., Murakami, Y., et al.Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studiesEur. J. Pharmacol.517(3),191-199(2005)
