LY320135
Cat. No.：YN322102
| 产品名称: | LY320135 |
| CAS No.: | 176977-56-3 |
| Chemical Name: | 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-benzonitrile |
| Synonyms: | LY 320135 |
| 分子量: | 383.40 |
| 分子式: | C₂₄H₁₇NO₄ |
| SMILES: | N#CC1=CC=C(C(C2=C(C3=CC=C(OC)C=C3)OC4=CC(OC)=CC=C24)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY320135是一种有效的和选择性的CB1受体拮抗剂，Ki值为 141 nM。LY320135 还与5-HT2和muscarinic receptors结合，Ki值分别为 6.4 μM 和 2.1 μM。LY320135具有神经保护作用。 |
| IC50和靶点: | [{name:"CB1:141 nM (Ki)"},{name: "5-HT2 Receptor:6.4 μM (Ki)"},{name: "muscarinic receptor:2.1 μM (Ki)"},{name: "CB2:>10 μM (Ki)"}] |
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Felder, C.C., Joyce, K.E., Briley, E.M., et al.LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulationJ. Pharmacol. Exp. Ther.284(1),291-297(1998)
Sanford, A.E., Castillo, E., and Gannon, R.L.Cannabinoids and hamster circadian activity rhythmsBrain Res.1222,141-148(2008)
