CV-6209
Cat. No.：YN322114
| 产品名称: | CV-6209 |
| CAS No.: | 100488-87-7 |
| Chemical Name: | 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium, monochloride |
| Synonyms: | CV 6209;CV6209 |
| 分子量: | 642.30952 |
| 分子式: | C34H60N3O6 • Cl |
| SMILES: | O=C(C)N(C(OCC(OC)COC(NCCCCCCCCCCCCCCCCCC)=O)=O)CC1=CC=CC=[N+]1CC.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CV-6209 是一种有效的血小板激活因子 (PAF) 拮抗剂。CV-6209 抑制 PAF 诱导的兔和人血小板聚集，IC50值分别为 75 nM 和 170 nM。CV-6209 可以抑制 PAF 引起的大鼠低血压。 |
| IC50和靶点: | |
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Terashita, Z., Imura, Y., Takatani, M., et al.CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivoJ. Pharmacol. Exp. Ther.242,263-268(1987)
Leong, H.S., Mahesh, B.M., Day, J.R., et al.Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factorJ. Leukoc. Biol.83(2),263-271(2008)
Musio, S., Pedotti, P., Mantegazza, R., et al.Anaphylaxis to a self-peptide in the absence of mast cells or histamineLab. Invest.89(4),398-405(2009)
