GAT211
Cat. No.：YN322128
CAS No. ：102704-40-5
| 产品名称: | GAT211 |
| CAS No.: | 102704-40-5 |
| Chemical Name: | 3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole |
| Synonyms: | GAT211 |
| 分子量: | 342.3906 |
| 分子式: | C22H18N2O2 |
| SMILES: | O=[N+](CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3)NC4=CC=CC=C42)[O-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GAT211 是一种大麻素 1 受体 (CB1R) 正变构调节剂 (PAM)，pKb 为 7.26。GAT211 对 cAMP 和 β-arrestin2 的 EC50分别为 260 nM，650 nM。GAT211 可用于神经性和/或炎症性疼痛的研究。 |
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Laprairie, R.B., Kulkarni, P.M., Deschamps, J.R., et al.Enantiospecific allosteric modulation of cannabinoid 1 receptorACS Chem Biol.8(6),1188-1203(2017)
Mitjavila, J., Yin, D., Kulkarni, P.M., et al.Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neuronsPharmacol. Res.129,475-481(2018)
Slivicki, R.A., Xu, Z., Kulkarni, P.M., et al.Positive allosteric modulation of CB1 suppresses pathological pain without producing tolerance or dependenceBiol. Psychiatry84(10),722-733(2018)
