CCG-100602
Cat. No.：YN322185
CAS No. ：1207113-88-9
| 产品名称: | CCG-100602 |
| CAS No.: | 1207113-88-9 |
| Chemical Name: | 1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)-3-piperidinecarboxamide |
| Synonyms: | |
| 分子量: | 478.8 |
| 分子式: | C21H17ClF6N2O2 |
| SMILES: | ClC(C=C1)=CC=C1NC(C(C2)CCCN2C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCG-100602 是心肌蛋白相关转录因子 A/血清反应因子 (MRTF-A/SRF) 信号转导的特异性抑制剂。CCG-100602 特异性阻断 MRTF-A 核定位，从而抑制纤维生成转录因子 SRF。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Evelyn, C.R., Wade, S.M., Wang, Q., et al.CCG-1423: A small-molecule inhibitor of RhoA transcriptional signalingMol. Cancer Ther.6(8),2249-2260(2007)
Evelyn, C.R., Bell, J.L., Ryu, J.G., et al.Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423Bioorg. Med. Chem. Lett.20(2),665-672(2010)
