MMPIP (hydrochloride)
Cat. No.：YN322189
CAS No. ：1215566-78-1
| 产品名称: | MMPIP (hydrochloride) |
| CAS No.: | 1215566-78-1 |
| Chemical Name: | 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one, monohydrochloride |
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| 分子量: | 369.8 |
| 分子式: | C19H15N3O3 • HCl |
| SMILES: | O=C1N(C)C(C2=CC=C(OC)C=C2)=CC3=C1C(C4=CC=NC=C4)=NO3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MMPIP hydrochloride 是一种变构的选择性代谢型谷氨酸受体7 (mGluR7) 拮抗剂 (KB值范围为 24-30 nM)。MMPIP hydrochloride 可用于研究mGluR7对中枢神经系统功能的作用。MMPIP hydrochloride 可减轻神经病小鼠的疼痛并使其情感和认知行为正常化。 |
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Suzuki, G., Tsukamoto, N., Fushiki, H., et al.In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonistsJ. Pharmacol. Exp. Ther.323(1),147-156(2007)
Niswender, C.M., Johnson, K.A., Miller, N.R., et al.Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7Mol. Pharmacol.77(3),459-468(2010)
Li, X., Li, J., Peng, X.Q., et al.Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: Involvement of a ventral pallidal GABAergic mechanismNeuropsychopharmacology34(7),1783-1796(2009)
Benn, A., and Robinson, E.S.J.Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time taskPLoS One9(12),(2014)
Palazzo, E., Romano, R., Luongo, L., et al.MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic micePain156(6),1060-1073(2015)
Kammemeier, P.J.Constitutive activity of metabotropic glutamate receptor 7BMC Neurosci.16:17,(2015)
