NIBR0213
Cat. No.：YN322198
| 产品名称: | NIBR0213 |
| CAS No.: | 1233332-14-3 |
| Chemical Name: | N-[[3'-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]-L-alanine |
| Synonyms: | |
| 分子量: | 465 |
| 分子式: | C27H29ClN2O3 |
| SMILES: | CC1=C(Cl)C=CC([C@@H](C)NC2=CC(C3=CC(C)=C(C(N[C@@H](C)C(O)=O)=O)C(C)=C3)=CC=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NIBR-0213 是一种有效的、具有口服活性的选择性S1P1拮抗剂，对实验性自身免疫性脑脊髓炎有效。在 GTPγ35S 试验中，NIBR-0213 有效作用于人和大鼠S1P1，IC50分别为 2.0 nM 和 2.3 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Quancard, J., Bollbuck, B., Janser, P., et al.A potent and selective S1P1 antagonist with efficacy in experimental autoimmune encephalomyelitisChem. Biol.19(9),1142-1151(2012)
Huwiler, A., Kolter, T., Pfeilschifter, J., et al.Physiology and pathophysiology of sphingolipid metabolism and signalingBiochim. Biophys. Acta1485(2-3),63-99(2000)
Bigaud, M., Dincer, Z., Bollbuck, B., et al.Pathophysiological consequences of a break in S1P1-dependent homeostasis of vascular permeability revealed by S1P1 competitive antagonismPLoS One11(12),e0168252(2016)
