Leucomethylene blue mesylate
Cat. No.：YN380329
CAS No. ：1236208-20-0
| 产品名称: | Leucomethylene blue mesylate |
| CAS No.: | 1236208-20-0 |
| Chemical Name: | N3,N3,N7,N7-tetramethyl-10H-phenothiazine-3,7-diamine, dimethanesulfonate |
| Synonyms: | TRx0237 mesylate; Methylene blue leuco base mesylate |
| 分子量: | 477.6216 |
| 分子式: | C16H19N3S • 2CH3SO3H |
| SMILES: | O=S(O)(C)=O.CN(C)C1=CC=C2NC3=CC=C(N(C)C)C=C3SC2=C1.O=S(O)(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Leucomethylene blue (TRx0237) mesylate 是具有口服活性的二代tau蛋白聚集的抑制剂 (Ki值为0.12 μM)，可用于阿尔兹海默症的研究。Leucomethylene blue mesylate 是 Methylene blue (亚甲基蓝)的一种还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。 |
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Harrington, C.R., Storey, J.M.D., Clunas, S., et al.Cellular models of aggregation-dependent template-directed proteolysis to characterize tau aggregation inhibitors for treatment of Alzheimer diseaseJ. Biol. Chem.290(17),10862-10875(2015)
Riedel, G., Klein, J., Niewiadomska, G., et al.Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse modelCurr. Alzheimer Res.17(3),285-296(2020)
