AM6545
Cat. No.：YN322203
| 产品名称: | AM6545 |
| CAS No.: | 1245626-05-4 |
| Chemical Name: | 5-[4-(4-cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide |
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| 分子量: | 556.5 |
| 分子式: | C26H23Cl2N5O3S |
| SMILES: | ClC1=CC(Cl)=C(N2N=C(C(NN3CCS(CC3)(=O)=O)=O)C(C)=C2C4=CC=C(C#CCCC#N)C=C4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AM6545 是一种具有外周活性的大麻素受体拮抗剂，具有有限的脑渗透。AM6545 与CB1和CB2受体结合，Ki分别为 1.7 nM 和 523 nM。AM6545 是一种中性拮抗剂。AM6545 可用于肥胖症及其并发症的研究。 |
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Cluny, N.L., Vemuri, V.K., Chambers, A.P., et al.A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodentsBr. J. Pharmacol.161(3),629-642(2010)
Randall, P.A., Vemuri, V.K., Segovia, K.N., et al.The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behaviorPharmacol. Biochem. Behav.97(1),179-184(2010)
Tam, J., Vemuri, V.K., Liu, J., et al.Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesityJ. Clin. Invest.120(8),2953-2966(2010)
