(Rac)-HAMI 3379
Cat. No.：YN322204
| 产品名称: | (Rac)-HAMI 3379 |
| CAS No.: | 1245653-57-9 |
| Chemical Name: | 3-[[[(1S,3S)-3-carboxycyclohexyl]amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]-benzoic acid |
| Synonyms: | HAMI 3379;HAMI-3379 |
| 分子量: | 595.7 |
| 分子式: | C34H45NO8 |
| SMILES: | O=C(N[C@H]1CCC[C@H](C(O)=O)C1)C2=CC(C(O)=O)=CC=C2OCCCC(C=C3)=CC=C3OCCCCOC4CCCCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HAMI 3379 是一种有效的选择性CysLT2受体拮抗剂。HAMI 3379 对急性和亚急性缺血性脑损伤具有保护作用，并减轻小胶质细胞相关炎症。 |
| IC50和靶点: | |
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Wunder, F., Tinel, H., Kast, R., et al.Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptorBr. J. Pharmacol.160(2),399-409(2010)
Yu, S., Chen, X., Li, X., et al.Neuroprotective effects of CysLTR antagonist on Streptococcus pneumoniae‑induced meningitis in ratsExp. Ther. Med.24(1),443(2022)
Shi, Q.J., Wang, H., Liu, Z.X., et al.HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in ratsNeuroscience291,53-69(2015)
Trinh, H.K.T., Suh, D.-H., Nguyen, T.V.T., et al.Characterization of cysteinyl leukotriene-related receptors and their interactions in a mouse model of asthmaProstaglandins Leukot. Essent. Fatty Acids141,17-23(2019)
