LSN2463359
Cat. No.：YN322249
CAS No. ：1401031-52-4
| 产品名称: | LSN2463359 |
| CAS No.: | 1401031-52-4 |
| Chemical Name: | N-(1-methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide |
| Synonyms: | LSN2463359; LSN-2463359; LSN 2463359. |
| 分子量: | 265.3 |
| 分子式: | C16H15N3O |
| SMILES: | O=C(NC(C)C)C(C=C1)=NC=C1C#CC2=CC=NC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LSN2463359 是代谢型谷氨酸 5 (mGlu5) 的正变构调节剂。LSN2463359 减弱了对竞争性 NMDA 受体拮抗剂给药的行为反应。LSN2463359 选择性地减弱在神经发育 MAM E17 模型中观察到的逆转学习缺陷。 |
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Gastambide, F., Cotel, M.-C., Gilmour, G., et al.Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulatorNeuropsychopharmacology37(4),1057-1066(2012)
Gilmour, G., Broad, L.M., Wafford, K.A., et al.In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the ratNeuropharmacology64,224-239(2013)
Gastambide, F., Gilmour, G., Robbins, T.W., et al.The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the ratNeuropharmacology64,240-247(2013)
