PF-543
Cat. No.：YN322253
CAS No. ：1415562-82-1
| 产品名称: | PF-543 |
| CAS No.: | 1415562-82-1 |
| Chemical Name: | |
| Synonyms: | Sphingosine Kinase 1 Inhibitor II |
| 分子量: | 465.6 |
| 分子式: | C27H31NO4S |
| SMILES: | N(CC1=CC=C(COC2=CC(CS(C3=CC=CC=C3)(=O)=O)=CC(C)=C2)C=C1)1CCC[C@H]1CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-543 (Sphingosine Kinase 1 Inhibitor II) 是一种有效，选择性，可逆和鞘氨醇竞争性SPHK1抑制剂，IC50为 2 nM，Ki为 3.6 nM。PF-543 对SPHK1的选择性是SPHK2的 100 倍以上。PF-543 还是有效的全血中 1-磷酸鞘氨醇 (S1P) 形成的有效抑制剂，IC50为 26.7 nM。PF-543 诱导细胞凋亡，坏死和自噬。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
