Brexpiprazole-d8
Cat. No.：YN322257
| 产品名称: | Brexpiprazole-d8 |
| CAS No.: | 1427049-21-5 |
| Chemical Name: | 7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)butoxy]-2(1H)-quinolinone |
| Synonyms: | OPC-34712-d |
| 分子量: | 441.61538 |
| 分子式: | C25H19D8N3O2S |
| SMILES: | O=C1C=CC2=C(C=C(OCCCCN3C([2H])([2H])C([2H])([2H])N(C4=C(C=CS5)C5=CC=C4)C([2H])([2H])C3([2H])[2H])C=C2)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brexpiprazole-d8是 Brexpiprazole (OPC-34712) 的氘代物。Brexpiprazole，一种非典型抗精神活性分子，是人 5-HT1A 和多巴胺受体的部分激动剂，Ki分别为 0.12 nM 和 0.3 nM。Brexpiprazole 也是 5-HT2A 受体的拮抗剂，Ki为 0.47 nM。 |
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Maeda, K., Sugino, H., Akazawa, H., et al.Brexpiprazole I: In vitro and in vivo characterization of a novel serotonin-dopamine activity modulatorJ. Pharmacol. Exp. Ther.350(3),589-604(2014)
Maeda, K., Lerdrup, L., Sugino, H., et al.Brexpiprazole II: Antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulatorJ. Pharmacol. Exp. Ther.350(3),605-614(2014)
