Eletriptan
Cat. No.：YN322261
| 产品名称: | Eletriptan |
| CAS No.: | 143322-58-1 |
| Chemical Name: | 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole |
| Synonyms: | UK-116044 |
| 分子量: | 382.5 |
| 分子式: | C22H26N2O2S |
| SMILES: | CN(CCC1)[C@H]1CC2=CNC3=CC=C(CCS(C4=CC=CC=C4)(=O)=O)C=C32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Eletriptan (UK-116044) 是一种高选择性且具有口服活性的5-HT1B和5-HT1D受体激动剂，pKi分别为 8.0 和 8.9。Eletriptan 对大鼠神经源性炎症标志物有抑制作用。Eletriptan 可用于偏头痛的研究。 |
| IC50和靶点: | [{name:"5-HT1B Receptor:8.0 (pKi)"},{name: "5-HT1D Receptor:8.9 (pKi)"}] |
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Akin, D., Onaran, H.O., and Gudal, H.Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid arteryBr. J. Pharmacol.136(2),171-176(2002)
Edvinsson, L., Uddman, E., Wackenfors, A., et al.Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: Relationship to clinical effectClin. Sci. (Lond.)109(3),335-342(2005)
