Quininib
Cat. No.：YN322263
| 产品名称: | Quininib |
| CAS No.: | 143816-42-6 |
| Chemical Name: | 2-[(1E)-2-(2-quinolinyl)ethenyl]-phenol |
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| 分子量: | 247.3 |
| 分子式: | C17H13NO |
| SMILES: | OC(C=CC=C1)=C1/C=C/C2=NC3=CC=CC=C3C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Quininib 是一种半胱氨酰白三烯 1 和 2 受体拮抗剂，对CysLT1R和CysLT2R的IC50分别为 1.2 和 52 μM。Quininib 是一种有效的斑马鱼眼发育性血管生成抑制剂。 Quininib可用于眼部新生血管病变的研究，可补充目前的抗VEGF生物制剂。 |
| IC50和靶点: | |
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Reynolds, A.L., Alvarez, Y., Sasore, T., et al.Phenotype-based discovery of 2-[(E)-2-(quinolin-2-yl)vinyl]phenol as a novel regulator of ocular angiogenesisJ. Biol. Chem.291(14),7242-7255(2016)
Murphy, A.G., Casey, R., Maguire, A., et al.Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancerSci. Rep.6,34523(2016)
