4F 4PP oxalate
Cat. No.：YN322267
CAS No. ：144734-36-1
| 产品名称: | 4F 4PP oxalate |
| CAS No.: | 144734-36-1 |
| Chemical Name: | (4-fluorophenyl)[1-(4-phenylbutyl)-4-piperidinyl]-methanone, monoethanedioate |
| Synonyms: | |
| 分子量: | 429.4812632 |
| 分子式: | C22H26FNO • C2H2O4 |
| SMILES: | O=C(C(O)=O)O.O=C(C1CCN(CC1)CCCCC2=CC=CC=C2)C3=CC=C(C=C3)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4F 4PP (oxalate) 是一种选择性5-HT2A拮抗剂，其亲和力几乎与酮色胺一样高 (Ki= 5.3 nM)，但对 5-HT2C 位点的亲和力要低得多 (Ki= 620 nM)。 |
| IC50和靶点: | [{name:"5-HT2A Receptor:5.3 nM (Ki)"},{name: "5-HT2C Receptor:620 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Herndon, J.L., Ismaiel, A., Ingher, S.P., et al.Ketanserin analogues: Structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor bindingJ. Med. Chem.35(26),4903-4910(1992)
Acuña-Castillo, C., Villalobos, C., Moya, P.R., et al.Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptorsBr. J. Pharmacol.136(4),510-519(2002)
Aira, Z., Buesa, I., Salgueiro, M., et al.Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injuryNeuroscience168(3),831-841(2010)
