A-77636 hydrochloride
Cat. No.：YN322270
| 产品名称: | A-77636 hydrochloride |
| CAS No.: | 145307-34-2 |
| Chemical Name: | (1R,3S)-1-(aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-1H-2-benzopyran-5,6-diol, monohydrochloride |
| Synonyms: | A-77636 (hydrochloride) |
| 分子量: | 365.89396 |
| 分子式: | C20H27NO3 • HCl |
| SMILES: | OC1=CC=C2C(C[C@@H](C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)O[C@H]2CN)=C1O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-77636 hydrochloride 是一种具有口服活性的、选择性的和长效多巴胺D1受体激动剂 (pKi=7.40;Ki=39.8 nM)，具有抗帕金森病活性。A-77636 hydrochloride 对多巴胺 D2 受体无功能活性。 |
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Kebabian, J.W., Britton, D.R., DeNinno, M.P., et al.A-77636: A potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosetsEur. J. Pharmacol.229(2-3),203-209(1992)
Lewis, M.M., Watts, V.J., Lawler, C.P., et al.Homologous desensitization of the D1A dopamine receptor: Efficacy in causing desensitization dissociates from both receptor occupancy and functional potencyJ. Pharmacol. Exp. Ther.286(1),345-353(1998)
Acquas, E., Day, J.C., and Fibiger, H.C.The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the ratEur. J. Pharmacol.260(1),85-87(1994)
