SC 51089
Cat. No.：YN322274
| 产品名称: | SC 51089 |
| CAS No.: | 146033-02-5 |
| Chemical Name: | 8-chloro-2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, monohydrochloride |
| Synonyms: | |
| 分子量: | 459.3 |
| 分子式: | C22H19ClN4O3 • HCl |
| SMILES: | O=C(CCc1ccncc1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SC 51089 是一种选择性的前列腺素受体EP1拮抗剂，对EP1，TP，EP3和FP受体的Ki值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 具有神经保护活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Abramovitz, M., Adam, M., Boie, Y., et al.The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogsBiochim. Biophys. Acta1483(2),285-293(2000)
Li, X., Rose, S.E., Montine, K.S., et al.Antagonism of neuronal prostaglandin E2 receptor subtype 1 mitigates amyloid β neurotoxicity in vitroJ. Neuroimmune Pharmacol.8(1),87-93(2016)
Matsuo, M., Yoshida, N., Zaitsu, M., et al.Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089J. Neurooncol.66,285-292(2004)
Hallinan, E.A., Hagen, T.J., Husa, R.K., et al.N-substituted dibenzoxazepines as analgesic PGE2 antagonistsJ. Med. Chem.36,3293-3299(1993)
