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Selegiline hydrochloride

Cat. No.:YN380342

  • CAS No. :14611-52-0

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    • 产品名称: Selegiline hydrochloride
      CAS No.: 14611-52-0
      Chemical Name: (R)-N,α-dimethyl-N-2-propyn-1-yl-benzeneethanamine, monohydrochloride
      Synonyms:盐酸司来吉兰; Deprenyl hydrochloride; (-
      分子量:223.7
      分子式:C13H17N • HCl
      SMILES:CN(CC#C)[C@H](C)CC1=CC=CC=C1.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Selegiline (Deprenyl) hydrochloride 是一种有效、选择性和不可逆的MAO-B抑制剂,IC50值为 51 nM。Selegiline hydrochloride 对MAO-B的选择性比MAO-A高 450 倍 (IC50=23 μM)。Selegiline hydrochloride 可用于帕金森氏病、阿尔茨海默病和重度抑郁症的研究。
      IC50和靶点: [{name:"MAO-B:51 nM (IC50)"}]
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Wimbiscus, M., Kostenko, O., and Malone, D.MAO inhibitors: Risks, benefits, and loreCleve. Clin. J. Med.77(12),859-882(2010)

      Jagrat, M., Behera, J., Yabanoglu, S., et al.Pyrazoline based MAO inhibitors: Synthesis, biological evaluation and SAR studiesBioorg. Med. Chem. Lett.21(14),4296-4300(2011)

      La Regina, G., Silvestri, R., Gatti, V., et al.Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and BBioorg. Med. Chem.16(22),9729-9740(2008)

      Hara, M.R., Thomas, B., Cascio, M.B., et al.Neuroprotection by pharmacologic blockade of the GAPDH death cascadeProc. Natl. Acad. Sci. USA103(10),3887-3889(2006)

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