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Diphenylpyraline

Cat. No.:YN322277

  • CAS No. :147-20-6

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    • 产品名称: Diphenylpyraline
      CAS No.: 147-20-6
      Chemical Name: 4-(diphenylmethoxy)-1-methyl-piperidine
      Synonyms:二苯拉林; 双苯拉林
      分子量:281.39206
      分子式:C19H23NO
      SMILES:CN(CC1)CCC1OC(C2=CC=CC=C2)C3=CC=CC=C3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Diphenylpyraline 是一种有效的组胺 H1 受体 (histamine H1receptor) 的拮抗剂。Diphenylpyraline 是一种具有口服活性抗组胺试剂,具有抗胆碱和抗过敏作用。Diphenylpyraline 可用于过敏性疾病,包括鼻炎和花粉热,以及瘙痒性皮肤疾病等的研究。
      IC50和靶点:
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    • Oleson, E.B., Ferris, M.J., España, R.A., et al.Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and rewardEur. J. Pharmacol.683(1-3),161-165(2012)

      Kubo, N., Shirakawa, S., Kuno, T., et al.Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assayJpn. J. Pharmacol.43(3),277-282(1987)

      Nakabou, Y., Kubota, M., Takada, K., et al.A possible approach to the suppression of side effects induced by PGE1Prostaglandins Leukot. Essent. Fatty Acids52(1),17-20(1995)

      Dulabh, R., and Vickers, M.R.The effects of H2-receptor antagonists on anaphylaxis in the guinea-pigAgents Actions8(6),559-565(1978)

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