hMAO-B/MB-COMT-IN-1
Cat. No.：YN380344
| 产品名称: | hMAO-B/MB-COMT-IN-1 |
| CAS No.: | 147700-11-6 |
| Chemical Name: | 8-[(1E)-2-(3-chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione |
| Synonyms: | |
| 分子量: | 330.76876 |
| 分子式: | C16H15ClN4O2 |
| SMILES: | O=C(N(C)C1=C2N(C)C(/C=C/C3=CC=CC(Cl)=C3)=N1)N(C)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (E)-8-(3-Chlorostyryl)caffeine 是一种选择性腺苷A2A受体拮抗剂。(E)-8-(3-Chlorostyryl)caffeine 通过独立于其对 A2A受体作用的途径抑制单胺氧化酶 B (MAO-B)，Ki值为 70 nM。(E)-8-(3-Chlorostyryl)caffeine 具有用于帕金森病研究的潜力。 |
| IC50和靶点: | |
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Jacobson, K.A., Nikodijević, O., Padgett, W.L., et al.8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivoFEBS Lett.323(1-2),141-144(1993)
Song, L., Kong, M., Ma, Y., et al.Inhibitory effect of 8-(3-chlorostryryl) caffeine on levodopa-induced motor fluctuation is associated with intracellular signaling pathway in 6-OHDA-lesioned ratsBrain Res.1276,171-179(2009)
Chen, J.-F., Steyn, S., Staal, R., et al.8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonismJ. Biol. Chem.277(39),36040-36044(2002)
