BMS-986120
Cat. No.：YN322280
CAS No. ：1478712-37-6
| 产品名称: | BMS-986120 |
| CAS No.: | 1478712-37-6 |
| Chemical Name: | 2-methoxy-6-[6-methoxy-4-[[5-methyl-2-(4-morpholinyl)-4-thiazolyl]methoxy]-2-benzofuranyl]-imidazo[2,1-b]-1,3,4-thiadiazole |
| Synonyms: | |
| 分子量: | 513.6 |
| 分子式: | C23H23N5O5S2 |
| SMILES: | COC1=CC2=C(C=C(C3=CN4C(SC(OC)=N4)=N3)O2)C(OCC5=C(C)SC(N6CCOCC6)=N5)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-986120 是first-in-class、具有口服活性的蛋白酶激活受体 4(PAR4)的可逆拮抗剂，在人类和猴子血液中的IC50值分别为 9.5 nM 和 2.1 nM。BMS-986120 具有有效选择性的抗血小板作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wong, P.C., Seiffert, D., Bird, J.E., et al.Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleedingSci. Transl. Med.9(371),eaaf5294(2017)
