NE-100 hydrochloride
Cat. No.：YN380346
| 产品名称: | NE-100 hydrochloride |
| CAS No.: | 149409-57-4 |
| Chemical Name: | 4-methoxy-3-(2-phenylethoxy)-N,N-dipropyl-benzeneethanamine, monohydrochloride |
| Synonyms: | NE100,NE 100 |
| 分子量: | 392 |
| 分子式: | C23H33NO2 • HCl |
| SMILES: | COC1=C(OCCC2=CC=CC=C2)C=C(CCN(CCC)CCC)C=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NE-100 (hydrochloride) 是一种有效的选择性sigma-1受体拮抗剂，IC50为 4.16 nM。NE-100 (hydrochloride) 在体内具有抗精神病活性。NE-100 (hydrochloride) 也能抑制内质网应激诱导的海马细胞死亡。 |
| IC50和靶点: | |
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Chaki, S., Tanaka, M., Muramatsu, M., et al.NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brainEur. J. Pharmacol.251(1),R1-2(1994)
Okuyama, S., Imagawa, Y., Ogawa, S., et al.NE-100, a novel sigma receptor ligand: in vivo testsLife Sci.53(18),PL285-PL290(1993)
Yamamoto, H., Yamamoto, T., Sagi, N., et al.NE-100, a novel sigma ligand: Effects on [3H]TCP binding to intact primary cultured neuronal cellsLife Sci.56(2),PL39-PL43(1995)
Dalwadi, D.A., Kim, S., and Schetz, J.A.Activation of the sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astrogliaNeurochem Int.105(5),27-31(2017)
Hong, J., Sha, S., Zhou, L., et al.Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neuronsCell Death Dis.6,e1832(2015)
