UCM 608
Cat. No.：YN322285
CAS No. ：151889-03-1
| 产品名称: | UCM 608 |
| CAS No.: | 151889-03-1 |
| Chemical Name: | N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]-acetamide |
| Synonyms: | 2-Phenylmelatonin |
| 分子量: | 308.37438 |
| 分子式: | C19H20N2O2 |
| SMILES: | O=C(C)NCCC1=C(C2=CC=CC=C2)NC3=C1C=C(C=C3)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UCM 608 是一种高亲和力的褪黑素 (MT) 膜受体激动剂。MT1和MT2的pKi值分别为 10.7 和 10.4。 |
| IC50和靶点: | |
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Nosjean, O., Nicolas, J.P., Klupsch, F., et al.Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2Biochem. Pharmacol.61(11),1369-1379(2001)
Nonno, R., Pannacci, M., Lucini, V., et al.Ligand efficacy and potency at recombinant human MT2 melatonin receptors: Evidence for agonist activity of some mt1-antagonistsBrit. J. Pharmacol.127(5),1288-1294(2016)
Santagostino-Barbone, M.G., Masoero, E., Spelta, V., et al.2-Phenylmelatonin: A partial agonist at enteric melatonin receptorsPharmacol. Toxicol.87(4),156-160(2000)
Pintor, J., Peláez, T., Hoyle, C.H.V., et al.Ocular hypotensive effects of melatonin receptor agonists in the rabbit: Further evidence for an MT3 receptorBr. J. Pharmacol.138(5),831-836(2003)
