SB 204741
Cat. No.：YN322287
| 产品名称: | SB 204741 |
| CAS No.: | 152239-46-8 |
| Chemical Name: | N-(1-methyl-1H-indol-5-yl)-N′-(3-methyl-5-isothiazolyl)-urea |
| Synonyms: | Urea,N-(1-methyl-1H-indol-5-yl)-N'-(3-methyl-5-isothiazolyl)-;1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea;SB 204741;Lopac-S-0693;N-(1-Methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea;N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-Methyl-5-isothiazo |
| 分子量: | 286.35332 |
| 分子式: | C14H14N4OS |
| SMILES: | O=C(NC1=CC(C=CN2C)=C2C=C1)NC3=CC(C)=NS3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB 204741 是一种选择性且高亲和性的5-HT2B拮抗剂，其pKi值为7.1。 |
| IC50和靶点: | [{name:"human 5-HT2B Receptor:7.1 (pKi)"}] |
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Forbes, I.T., Jones, G.E., Murphy, O.E., et al.N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: A novel, high-affinity 5-HT2B receptor antagonistJ. Med. Chem.38(6),855-857(1995)
West, J.D., Carrier, E.J., Bloodworth, N.C., et al.Serotonin 2B receptor antagonism prevents heritable pulmonary arterial hypertensionPLoS One11(2),e0148657(2016)
Shingala, J.R., and Balaraman, R.Antihypertensive effect of 5-HT1A agonist buspirone and 5-HT2B antagonists in experimentally induced hypertension in ratsPharmacology73(3),129-139(2005)
