BAY-u 9773
Cat. No.：YN322292
CAS No. ：154978-38-8
| 产品名称: | BAY-u 9773 |
| CAS No.: | 154978-38-8 |
| Chemical Name: | 4-[[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]thio]-benzoic acid |
| Synonyms: | |
| 分子量: | 472.6 |
| 分子式: | C27H36O5S |
| SMILES: | CCCCC/C=C\C\C=C/C=C\C=C/[C@@H](Sc1ccc(cc1)C(=O)O)C(O)CCCC(=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY-u 9773 是一种非选择性的CysLT 受体(半胱氨酸白三烯受体)拮抗剂，对于 CysLT1和 CysLT2的 IC50值大约相等，用于抑制白三烯反应。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tudhope, S.R., Cuthbert, N.J., Abram, T.S., et al.BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypesEur. J. Pharmacol.264,317-323(1994)
Muraki, M., Imbe, S., Santo, H., et al.Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma modelInt. Arch. Allergy Appl. Immunol.155(Suppl. 1),90-95(2011)
Lenz, Q.F., Arroyo, D.S., Temp, F.R., et al.Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunctionNeuroscience277,859-871(2014)
