BIBP3226
Cat. No.：YN322297
| 产品名称: | BIBP3226 |
| CAS No.: | 159013-54-4 |
| Chemical Name: | N-[(1R)-4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenyl-benzeneacetamide |
| Synonyms: | |
| 分子量: | 473.56694 |
| 分子式: | C27H31N5O3 |
| SMILES: | OC(C=C1)=CC=C1CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIBP3226 是一种有效选择性的神经肽 Y Y1(NPY Y1)和神经肽 FF(NPFF)受体拮抗剂，对 rNPY Y1，hNPFF2，rNPFF 的Ki分别为 1.1、79、108 nM。BIBP3226 具有焦虑样作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mollereau, C., Gouardères, C., Dumont, Y., et al.Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226Br. J. Pharmacol.133(1),1-4(2001)
Rudolf, K., Eberlein, W., Engel, W., et al.The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226Eur. J. Pharmacol.271(2-3),R11-R13(1994)
Fang, Q., Guo, J., He, F., et al.In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonistPeptides27(9),2207-2213(2006)
