TCS-OX2-29 hydrochloride
Cat. No.：YN322302
| 产品名称: | TCS-OX2-29 hydrochloride |
| CAS No.: | 1610882-30-8 |
| Chemical Name: | (2S)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone, monohydrochloride |
| Synonyms: | OX2R antagonist |
| 分子量: | 434 |
| 分子式: | C23H31N3O3 • HCl |
| SMILES: | COC1=C(OC)C=C(CN(C([C@H](C(C)(C)C)NCC2=CC=NC=C2)=O)CC3)C3=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TCS-OX2-29 (hydrochloride) 是一种有效的，高亲和力和选择性的OX2R拮抗剂，其IC50值为 40 nM，pKI值为 7.5。与 OX1相比，TCS-OX2-29 对OX2的选择性约高了 250倍。 |
| IC50和靶点: | |
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Mould, R., Brown, J., Marshall, F.H., et al.Binding kinetics differentiates functional antagonism of orexin-2 receptor ligandsBr. J. Pharmacol.171(2),351-363(2014)
Hirose, M., Egashira, S.i., Goto, Y., et al.N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonistBioorg. Med. Chem. Lett.13(24),4497-4499(2003)
Urbanska, A., Sokolowska, P., Woldan-Tambor, A., et al.Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal culturesJ. Mol. Neurosci.46(1),10-17(2012)
