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DCG-IV

Cat. No.:YN322304

  • CAS No. :1623101-11-0

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    • 产品名称: DCG-IV
      CAS No.: 1623101-11-0
      Chemical Name: 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide
      Synonyms:VU0483605, VU-0483605, VU 048360
      分子量:446.7
      分子式:C20H10Cl3N3O3
      SMILES:O=C1N(C2=CC=C(NC(C3=C(Cl)C=CC=N3)=O)C=C2Cl)C(C4=CC=CC(Cl)=C41)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: VU0483605 是一种有效的可透过血脑屏障的mGlu1受体正向变构调节剂 (PAM)。VU0483605 对人源mGlu1和大鼠mGlu1均表现出良好的正向变构调节活性,其EC50值分别为 390 和 356 nM。
      IC50和靶点: [{name:"Human mGluR1:390 nM (EC50)"},{name: "rat mGluR1:356 nM (EC50)"},{name: "Human mGlu4:>10 μM (EC50)"}]
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    • Sheffler, D.J., and Conn, P.J.Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cellsNeuropharmacology55(4),419-427(2008)

      Cho, H.P., Garcia-Barrantes, P.M., Brogan, J.T., et al.Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsACS Chem. Biol.9(10),2234-2246(2014)

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