DCG-IV
Cat. No.:YN322304
CAS No. :1623101-11-0
产品名称: | DCG-IV |
CAS No.: | 1623101-11-0 |
Chemical Name: | 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide |
Synonyms: | VU0483605, VU-0483605, VU 048360 |
分子量: | 446.7 |
分子式: | C20H10Cl3N3O3 |
SMILES: | O=C1N(C2=CC=C(NC(C3=C(Cl)C=CC=N3)=O)C=C2Cl)C(C4=CC=CC(Cl)=C41)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | VU0483605 是一种有效的可透过血脑屏障的mGlu1受体正向变构调节剂 (PAM)。VU0483605 对人源mGlu1和大鼠mGlu1均表现出良好的正向变构调节活性,其EC50值分别为 390 和 356 nM。 |
IC50和靶点: | [{name:"Human mGluR1:390 nM (EC50)"},{name: "rat mGluR1:356 nM (EC50)"},{name: "Human mGlu4:>10 μM (EC50)"}] |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Sheffler, D.J., and Conn, P.J.Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cellsNeuropharmacology55(4),419-427(2008)
Cho, H.P., Garcia-Barrantes, P.M., Brogan, J.T., et al.Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsACS Chem. Biol.9(10),2234-2246(2014)