Synaptamide
Cat. No.：YN322307
CAS No. ：162758-94-3
| 产品名称: | Synaptamide |
| CAS No.: | 162758-94-3 |
| Chemical Name: | N-(2-hydroxyethyl)-4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenamide |
| Synonyms: | Dehydroepiandrosteron(DHEA |
| 分子量: | 371.6 |
| 分子式: | C24H37NO2 |
| SMILES: | OCCNC(=O)CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Synaptamide (Dehydroepiandrosteron; DHEA) 是一种内源性代谢物，是 Anandamide 的结构类似物。Synaptamide 与大麻素-1 和 2 (CB1 和 CB2) 大麻素受体结合并具有抗炎特性。Synaptamide 第一个粘附 G 蛋白偶联受体 (aGPCR) 的小分子内源性配体。 |
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Bisogno, T., Delton-Vandenbroucke, I., Milone, A., et al.Biosynthesis and inactivation of N-Arachidonoylethanolamine (Ananadamide) and N-Docosahexaenoylethanolamine in bovine retinaArch. Biochem. Biophys.370(2),300-307(1999)
Berger, A., Crozier, G., Bisogno, T., et al.Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in pigletsProc. Natl. Acad. Sci. USA98(11),6402-6406(2001)
Sheskin, T., Hanus, L., Slager, J., et al.Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptorJ. Med. Chem.40(5),659-667(1997)
Poling, J.S., Rogawski, M.A., Salem, N., Jr., et al.Anadamide, an endogenous cannabinoid, inhibits shaker-related voltage-gated K+ channelsNeuropharmacology35(7),983-991(1996)
