VU0422288
Cat. No.：YN322311
| 产品名称: | VU0422288 |
| CAS No.: | 1630936-95-6 |
| Chemical Name: | N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide |
| Synonyms: | ML396 |
| 分子量: | 360.19366 |
| 分子式: | C17H11Cl2N3O2 |
| SMILES: | O=C(NC1=CC(Cl)=C(OC2=CC=C(Cl)C=N2)C=C1)C3=CC=CC=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VU0422288 (ML396) 是 III 型 mGlu 受体 (mGlus) 的正变构调节剂。在钙动员试验中，VU0422288 对mGluR4、mGluR7和mGluR8的EC50值分别为 125 nM、146 nM 和 108 nM。VU0422288 在 Rett 综合症 (RTT) 模型小鼠中，可逆转其情境恐惧记忆、社会认知和呼吸暂停的缺陷。 |
| IC50和靶点: | [{name:"mGluR4:108 nM (EC50)"},{name: "mGluR7:146 nM (EC50)"},{name: "mGluR8:128 nM (EC50)"}] |
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Jalan-Sakrikar, N., Field, J.R., Klar, R., et al.Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7ACS Chem. Neurosci.5(12),1221-1237(2014)
Gogliotti, R.G., Senter, R.K., Fisher, N.M., et al.mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndromeSci. Transl. Med.9(403),(2017)
