Carbetocin acetate
Cat. No.：YN322312
CAS No. ：1631754-28-3
| 产品名称: | Carbetocin acetate |
| CAS No.: | 1631754-28-3 |
| Chemical Name: | N-(4-mercapto-1-oxobutyl)-O-methyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide, cyclic (1→5)-thioether, acetate |
| Synonyms: | 卡贝缩宫素醋酸盐 |
| 分子量: | 988.1623 |
| 分子式: | C45H69N11O12S • XC2H4O2 |
| SMILES: | O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([C@@H](C)CC)([H])NC1=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CSCCCC(N[C@H]1CC2=CC=C(OC)C=C2)=O)N3[C@H](C(N[C@@H](CC(C)C)C(NCC(N)=O)=O)=O)CCC3.CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Carbetocin acetate 是一种催产素 (OT) 类似物，是催产素受体 (oxytocin receptor) 激动剂，Ki是 7.1 nM。Carbetocin acetate 对催产素受体的嵌合 N 末端 (E1) 具有高亲和力 (Ki=1.17 μM)。Carbetocin acetate 具有用于产后出血研究的潜力。Carbetocin acetate 能透过血脑屏障，可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性。 |
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Engstrøm, T., Barth, T., Melin, P., et al.Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradationEur. J. Pharmacol.355(2-3),203-210(1998)
Bajcsy, Á.C., Szenci, O., van der Weijden, G.C., et al.The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cowsTheriogenology65(2),400-414(2006)
Zanos, P., Georgiou, P., Wright, S.R., et al.The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent miceNeuropsychopharmacology39(4),855-865(2014)
Meng, X., Shen, F., Li, C., et al.Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocinPharmacol. Biochem. Behav.145,1-8(2016)
