L-Stepholidine
Cat. No.：YN322317
| 产品名称: | L-Stepholidine |
| CAS No.: | 16562-13-3 |
| Chemical Name: | (13aS)-5,8,13,13a-tetrahydro-3,9-dimethoxy-6H-dibenzo[a,g]quinolizine-2,10-diol |
| Synonyms: | Stepholidine; (- |
| 分子量: | 327.37438 |
| 分子式: | C19H21NO4 |
| SMILES: | OC1=CC2=C(C=C1OC)CCN3CC4=C(OC)C(O)=CC=C4C[C@]32[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-Stepholidine (Stepholidine)，一种从中草药Stephania intermedia提取的生物碱，是已知的第一种同时具有多巴胺受体 D1(dopamine D1 receptor)激动剂和多巴胺受体 D2(dopamine D2 receptor)拮抗剂。L-Stepholidine 具有神经保护作用，并抑制海洛因诱导的恢复。L-Stepholidine 是研究阿片成瘾的一种潜在试剂。 |
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Meade, J.A., Free, R.B., Miller, N.R., et al.(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signalingPsychopharmacology232(5),917-630(2015)
Mo, J., Zhang, H., Yu, L.-P., et al.L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's diseaseNeurobiol. Aging31(6),926-936(2010)
Gao, M., Chu, H.-Y., Jin, G.-Z., et al.l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT1A receptor partial agonistic activitySynapse65(5),379-387(2011)
Natesan, S., Reckless, G.E., Barlow, K.B.L., et al.The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonistPsychopharmacology199(2),275-289(2008)
