JZP-361
Cat. No.：YN322319
CAS No. ：1680193-80-9
| 产品名称: | JZP-361 |
| CAS No.: | 1680193-80-9 |
| Chemical Name: | [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone |
| Synonyms: | |
| 分子量: | 405.88 |
| 分子式: | C22H20ClN5O |
| SMILES: | O=C(N(CC/1)CCC1=C2C3=C(CCC4=C/2N=CC=C4)C=C(C=C3)Cl)N5N=CN=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JZP-361是一种有效的、可逆的、选择性的人重组MAGL(hMAGL) 抑制剂，IC50为 46 nM。JZP-361 还具有抗组胺能活性，可用于哮喘的研究。 |
| IC50和靶点: | [{name:"hMAGL:46 nM (IC50)"},{name: "hABHD6:1.79 μM (IC50)"},{name: "hFAAH:7.24 μM (IC50)"},{name: "H1 Receptor:6.81 (pA2)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Patel, J.Z.
et al.: Bioorganic Med. Chem. Lett., 25, 1436 (2015)
