ML-00253764 hydrochloride
Cat. No.：YN322326
CAS No. ：1706524-94-8
| 产品名称: | ML-00253764 hydrochloride |
| CAS No.: | 1706524-94-8 |
| Chemical Name: | 2-[2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole, monohydrochloride |
| Synonyms: | ML 00253764 |
| 分子量: | 413.7 |
| 分子式: | C18H18BrFN2O • HCl |
| SMILES: | BrC1=CC=C(OC)C(CCC2=C(F)C=CC=C2C3=NCCN3)=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML-00253764 是一种非肽类黑皮质素受体 4 (MC4R) 拮抗剂，其Ki和IC50值分别为 0.16 µM 和 0.103 µM。脑渗透剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Vos, T.J., Caracoti, A., Che, J.L., et al.Identification of 2-{2-[2-(5-bromo-2methoxyphenyl)-ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse modelJ. Med. Chem.47(7),1602-1604(2004)
Nicholson, J.R., Kohler, G., Schaerer, F., et al.Peripheral administration of a melanocortin 4-receptor inverse agonist prevents loss of lean body mass in tumor-bearing miceJ. Pharmacol. Exp. Ther.317(2),(2006)
