α-MSH TFA
Cat. No.：YN322329
| 产品名称: | α-MSH TFA |
| CAS No.: | 171869-93-5 |
| Chemical Name: | |
| Synonyms: | α-Melanocyte-Stimulating Hormone TFA |
| 分子量: | 1664.8855 |
| 分子式: | C77H109N21O19S • XCF3COOH |
| SMILES: | O=C(NCC(N[C@@H](CCCCN)C(N(CCC1)[C@@H]1C(N[C@H](C(N)=O)C(C)C)=O)=O)=O)[C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC(C)=O)=O)CC(C=C2)=CC=C2O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | α-MSH (alpha-melanocyte-stimulating hormone) TFA 作为内源性神经肽，是一种内源性melanocortin receptor4 (MC4R)激动剂，具有抗炎、解热作用。α-MSH TFA 是前阿皮黑素皮质激素 (POMC) 的翻译后衍生物。 |
| IC50和靶点: | |
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Catania, A., Airaghi, L., Colombo, G., et al.α-melanocyte-stimulating hormone in normal human physiology and disease statesTrends Endocrinol. Metab.11(8),304-308(2000)
Miwa, H., Gantz, I., Konda, Y., et al.Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptorsJ. Pharmacol. Exp. Ther.273(1),367-372(1995)
Cutuli, M., Cristiani, S., Lipton, J.M., et al.Antimicrobial effects of a-MSH peptidesJ. Leukoc. Biol.67(2),233-239(2000)
Lipton, J.M., Ceriani, G., Macaluso, A., et al.Antiinflammatory effect of the neuropeptide a-MSH in acute, chronic, and systemic inflammationAnn. N. Y. Acad. Sci.25(741),137-148(1994)
