Oxotremorine sesquifumarate
Cat. No.：YN322331
| 产品名称: | Oxotremorine sesquifumarate |
| CAS No.: | 17360-35-9 |
| Chemical Name: | 1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-2-pyrrolidinone, 2E-butenedioate (2:3) |
| Synonyms: | |
| 分子量: | 380.4 |
| 分子式: | C12H18N2O • 3/2C4H4O4 |
| SMILES: | O=C1N(CC#CCN2CCCC2)CCC1.O=C3N(CC#CCN4CCCC4)CCC3.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oxotremorine sesquifumarate 是一种mAChR 激动剂，对 M2 的激活作用更强，可用于神经学研究。 |
| IC50和靶点: | |
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Jakubík, I., Bacáková, L., El-Fakahany, E.E., et al.Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptorsMol. Pharmacol.52(1),172-179(1997)
Szerb, J.C., and Somogyi, G.T.Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorineNat. New Biol.241(108),121-122(1973)
Moon, M.W., Chidester, C.G., Heier, R.F., et al.Cholinergic activity of acetylenic imidazoles and related compoundsJ. Med. Chem.34(8),2314-2327(1991)
Pleuvry, B.J., and Tobias, M.A.Comparison of the antinociceptive activities of physostigmine, oxotremorine and morphine in the mouseBr. J. Pharmacol.43(4),706-714(1971)
Castensson, S., Sievertsson, H., Lindeke, B., et al.Studies on the inhibition of oxotremorine induced tremor by a melanocyte-stimulating hormone release-inhibiting factor, thyrotropin releasing hormone and related peptidesFEBS Lett.44(1),101-105(1974)
