RP-001 hydrochloride
Cat. No.：YN322338
| 产品名称: | RP-001 hydrochloride |
| CAS No.: | 1781880-34-9 |
| Chemical Name: | N-[4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine, monohydrochloride |
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| 分子量: | 468.9 |
| 分子式: | C24H24N4O4 • HCl |
| SMILES: | OC(CCNC1CCC2=C(C3=NOC(C4=CC(C#N)=C(OC(C)C)C=C4)=N3)C=CC=C21)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RP-001 hydrochloride 是一种短效皮摩尔效力的S1P1 (EDG1)选择性激动剂，EC50为 9 pM。RP-001 hydrochloride 诱导 S1P1 内化和多泛素化。RP-001 hydrochloride 对 S1P2-S1P4 几乎没有活性，对 S1P5 只有中等亲和力。 |
| IC50和靶点: | |
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Cahalan, S.M., Gonzalez-Cabrera, P.J., Sarkisyan, G., et al.Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in miceNat. Chem. Biol.7(5),254-256(2011)
Huppé, C.A., Lecours, P.B., Lechasseur, A., et al.A sphingosine-1-phosphate receptor 1 agonist inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lungMucosal. Immunol.11(1),112-119(2018)
