Zicronapine fumarate
Cat. No.：YN322341
| 产品名称: | Zicronapine fumarate |
| CAS No.: | 1782532-06-2 |
| Chemical Name: | 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one, dihydrochloride |
| Synonyms: | |
| 分子量: | 422.39068 |
| 分子式: | C22H27N3O • 2HCl |
| SMILES: | O=C1NC(CCN2CCN(CC2)C3=CC(C)=C(C)C=C3)C4=CC=CC=C14.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD 168568 dihydrochloride 是一种口服有效的多巴胺受体 D4(DRD4) 拮抗剂。PD 168568 dihydrochloride 含有异吲哚啉酮，对 D4受体相对于 D2和 D3具有选择性，其Ki值分别为 8.8、1842 和 2682 nM。PD 168568 dihydrochloride 可用于胶质母细胞瘤 (GBM) 研究。 |
| IC50和靶点: | [{name:"D4 Receptor:8.8 nM (Ki)"},{name: "D2 Receptor:1842 nM (Ki)"},{name: "D3 Receptor:2682 nM (Ki)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Belliotti, T.R., Brink, W.A., Kesten, S.R., et al.Isoindolinone enantiomers having affinity for the dopamine D4 receptorBioorg. Med. Chem. Lett.8(12),1499-1502(1998)
Dolma, S., Selvadurai, H.J., Lan, X., et al.Inhibition of dopamine receptor D4 impedes autophagic flux, proliferation, and survival of glioblastoma stem cellsCancer Cell29(6),859-873(2016)
