AR420626
Cat. No.：YN322345
CAS No. ：1798310-55-0
| 产品名称: | AR420626 |
| CAS No.: | 1798310-55-0 |
| Chemical Name: | N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxamide |
| Synonyms: | AR-420626; AR 420626; AR420626. |
| 分子量: | 417.3 |
| 分子式: | C21H18Cl2N2O3 |
| SMILES: | ClC1=CC(NC(C2=C(C)NC(CCCC3=O)=C3C2C4=CC=CO4)=O)=C(Cl)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AR420626 是游离脂肪酸受体3 (FFAR3, GPR41)的选择性激动剂，IC50为117 nM。AR420626 抑制尼古丁和 5-羟色胺诱导的大鼠结肠离体肌条运动的变化，并抑制 5-羟色胺诱导的大鼠排便。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Inoue, D., Tsujimoto, G., and Kimura, I.Regulation of energy homeostasis by GPR41Front. Endocrinol. (Lausanne)5,1-3(2014)
Engelstoft, M.S., Park, W.m., Sakata, I., et al.Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cellsMol. Metab.2(4),376-392(2013)
Nohr, M.K., Pedersen, M.H., Gille, A., et al.GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytesEndocrinology154(10),3552-3564(2013)
