Dersimelagon
Cat. No.：YN322349
CAS No. ：1835256-48-8
| 产品名称: | Dersimelagon |
| CAS No.: | 1835256-48-8 |
| Chemical Name: | |
| Synonyms: | MT-7117 |
| 分子量: | 675.766 |
| 分子式: | C36H45F4N3O5 |
| SMILES: | N(C1=CC(C(F)(F)F)=CC=C1[C@H]1[C@H](COC)CN(C([C@@](F)2[C@@H](C3=CC=C(OC)C=C3)CN(C3CCCC3)C2)=O)C1)1CCC(C(O)=O)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dersimelagon (MT-7117) 是一种具有口服活性的选择性黑皮质素 1 受体(MC1R) 激动剂，对人 (h)、食蟹猴 (cm)、小鼠 (m) 和大鼠 (r)MC1R的EC50值分别为 8.16、3.91、1.14 和 0.251 nM。Dersimelagon 对 hMC1R 和 hMC4R 表现出良好的亲和力，Ki值分别为 2.26 和 32.9 nM。Dersimelagon可用于皮肤色素沉着的研究。 |
| IC50和靶点: | [{name:"hMC1R:2.26 nM (Ki)"},{name: "hMC3R:1420 nM (Ki)"},{name: "hMC4R:32.9 nM (Ki)"},{name: "hMC5R:486 nM (Ki)"},{name: "hMC1R:8.16 nM (EC50)"},{name: "cmMC1R:3.91 nM (EC50)"},{name: "mMC1R:1.14 nM (EC50)"},{name: "hMC4R:79.6 nM (EC50)"},{name: "hMC2R:>10000 nM (EC50)"},{name: "rMC1R:0.251 nM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
