NQTrp
Cat. No.：YN380357
CAS No. ：185351-19-3
| 产品名称: | NQTrp |
| CAS No.: | 185351-19-3 |
| Chemical Name: | N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan |
| Synonyms: | 1,4-Naphthoquinon-2-yl-l-tryptophan;N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan |
| 分子量: | 360.4 |
| 分子式: | C21H16N2O4 |
| SMILES: | O=C(C=C(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)C3=O)C4=C3C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NQTrp，一种芳香萘醌-色氨酸杂交分子，是 tau 蛋白 (tau protein) 聚集的抑制剂，具有抗淀粉样蛋白活性。NQTrp 抑制六肽 (41GCWMLY46，γD-crystallin 的 N 端)和全长 γD-crystallin 的体外聚集。 |
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Scherzer-Attali, R., Pellarin, R., Convertino, M., et al.Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitorPLoS One5(6),(2010)
Zhang, T., Xu, W., Mu, Y., et al.Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicityACS Chem. Neurosci.5(2),148-159(2016)
