Asimadoline hydrochloride
Cat. No.：YN322354
| 产品名称: | Asimadoline hydrochloride |
| CAS No.: | 185951-07-9 |
| Chemical Name: | N-[(1S)-2-[(3S)-3-Hydroxy-1-pyrrolidinyl]-1-phenylethyl]-N-methyl-α-phenylbenzeneacetamide Monohydrochloride;[S-(R*,R*)]-N-[2-(3-Hydroxy-1-pyrrolidinyl)-1-phenylethyl]-N-methyl-α-phenylbenzeneacetamide Monohydrochloride; |
| Synonyms: | 阿西马朵林盐酸盐; EMD-61753 hydrochloride |
| 分子量: | 451 |
| 分子式: | C27H30N2O2.ClH |
| SMILES: | CN(C(CN1CCC(C1)O)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Asimadoline (EMD-61753) hydrochloride 是一种口服有效的，选择性的，具有周边活性的κ-opioid激动剂，对豚鼠和人重组 κ-opioid 的IC50s 分别为 5.6 nM 和 1.2 nM。Asimadoline hydrochloride 对血脑屏障的渗透性低，具有外周抗炎作用。Asimadoline hydrochloride 可改善糖尿病大鼠的异常性疼痛，并具有用于肠易激综合征 (IBS) 研究的潜力。 |
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| Solvent & Solubility: |
Mangel, A. et al.: Clin. Exp. Gastroenterol., 5, 1 (2012)
