RS-102221
Cat. No.：YN322355
CAS No. ：187397-18-8
| 产品名称: | RS-102221 |
| CAS No.: | 187397-18-8 |
| Chemical Name: | N-[5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)-benzenesulfonamide, monohydrochloride |
| Synonyms: | RS102221;RS-102221 |
| 分子量: | 649.0796496 |
| 分子式: | C27H31F3N4O7S • HCl |
| SMILES: | O=C(C1=CC(NS(=O)(C2=CC=C(C(F)(F)F)C=C2)=O)=C(C=C1OC)OC)CCCCN3CCC4(NC(NC4=O)=O)CC3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RS-102221 hydrochloride 是一种选择性5-HT2C受体拮抗剂 (Ki=10 nM)。RS-102221 hydrochloride 对5-HT2C受体的选择性是5-HT2A和5-HT2B受体的近 100 倍。RS-102221 hydrochloride 能够促进新生神经细胞分化。RS-102221 hydrochloride 增加了大鼠的食物摄入量和体重增加。 |
| IC50和靶点: | [{name:"5-HT2C Receptor:10 nM (Ki)'}, '5-HT2A Receptor', '5-HT2B Receptor'] |
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Bonhaus, D.W., Weinhardt, K.K., Taylor, M., et al.RS-102221: A novel high affinity and selective, 5-HT2C receptor antagonistNeuropharmacology36(4-5),621-629(1997)
Kuznetsova, E.G., Amstislavskaya, T.G., Shefer, E.A., et al.Effect of 5-HT2C receptor antagonist RS 102221 on mouse behaviorBull. Exp. Biol. Med.142(1),76-79(2006)
